1 Department of Medical Laboratory Science, Ladoke Akintola University of Technology, Ogbomosho, Oyo State, Nigeria.
2 Department of Medical Laboratory Science, Ogun State Polytechnic of Health and Allied Sciences. Ile Ijebu, Ogun State Nigeria.
3 Department of Chemical Pathology, Ladoke Akintola University of Technology, Ogbomosho, Oyo State, Nigeria.
4 Department of Clinical Pharmacology, Faculty of Basic Clinical Sciences, Federal University of Health Sciences, Azare, Bauchi State, Nigeria.
5 Department of Medical Laboratory Science, Ogun State Hospital, Ijebu-Ife, Ogun State, Nigeria.
World Journal of Advanced Research and Reviews, 2025, 25(02), 1158-1169
Article DOI: 10.30574/wjarr.2025.25.2.0352
Received on 25 December 2024; revised on 04 February 2025; accepted on 07 February 2025
Background: Parturition, or the process of childbirth, is a critical physiological event associated with significant changes in hematology and coagulation. While these changes are often adaptive, they may also predispose mothers to complications such as anemia, thrombosis, or coagulopathy. Understanding these alterations is essential for optimizing maternal care during and after delivery. This study investigates the impact of parturition on hematological and coagulation parameters to identify key changes and their potential clinical implications.
Methodology: A prospective observational study was conducted involving 160 pregnant women attending LAUTECH teaching hospital, Ogbomosho. Between June and December, 2024. Blood samples were collected at two stages: late-third trimester and early postpartum period. Full blood count and coagulatory profiles were assayed using standard procedures and values were statistically compared across the two stages and correlate with maternal outcomes using standard procedures in all.
Results: Significant elevation in WBC (p = 0.006), neutrophil (p= 0.046) and basophil (p = 0.009) were observed postpartum, as well as significant reductions in hemoglobin and hematocrit (p = 0.044) and (p = 0.009). Also, there were significant increase in incidence of severe, moderate and mild anemia in postpartum. Protein S and PTTK were significantly shortened as well (p < 0.005), reflecting temporary changes in coagulation dynamics.
Conclusion: Parturition induces marked changes in hematology and coagulation parameters, reflecting the physiological adaptation to childbirth and associated blood loss. While most changes are transient, close monitoring is essential to identify and manage deviations that may indicate underlying complications. Routine assessment of hematological and coagulation profiles during the peripartum period is recommended to facilitate early detection and management of potential complications.
Anemia; Parturition; Postpartum; Hypercoagulation; Complica
Preview Article PDF
Kikelomo Olayemi Oyeleke, Monininuola Victoria Aborisade, Ibrahim Eleha Suleiman, Ahmed Olalekan Yusuf, Saheed Olawale Asimiyu, Oluyinka Bamidele Aborisade and Motolani Susan Borisade. Hypercoagulation and Anemia: The predominant parturition-associated coagulatory and hematological abnormality in Ogbomosho southwest, Nigeria. World Journal of Advanced Research and Reviews, 2025, 25(02), 1158-1169. Article DOI: https://doi.org/10.30574/wjarr.2025.25.2.0352.
Copyright © 2025 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0