1 Department of Chemical Pathology, faculty of basic clinical Sciences, Nnamdi Azikiwe University, Awka.
2 Department of Human Biochemistry, faculty of basic medical Sciences, Nnamdi Azikiwe University Awka.
3 Department of Obstetrics and Gyneacology, Faculty of Medicine, Nnamdi Azikiwe University, Awka.
4 Department of Clinical Chemistry, faculty Medical Laboratory Sciences, Nnamdi Azikiwe University Awka.
5 Department of Medical Laboratory Sciences, faculty of health sciences and technology, Chukwuemeka Odumegwu Ojukwu University, Igbariam.
World Journal of Advanced Research and Reviews, 2025, 27(01), 818-822
Article DOI: 10.30574/wjarr.2025.27.1.2471
Received on 18 May 2025; revised on 01 July 2025; accepted on 04 July 2025
Background: Regular physiological changes in pregnancy pose a metabolic challenge to individuals due to modifications the body makes for fetal growth and development, resulting in increased insulin resistance, inflammation and alterations in body composition, lipid levels and haemodynamic factors.
Objective: This study evaluates the lipid profile changes at different trimesters of pregnancy in pregnant women with proteinuria and glycosuria in Nnewi Anambra State.
Methods: A cross-sectional comparative study was conducted involving two hundred and fifty-two pregnant women categorized by trimester. Anthropometric and biochemical parameters including triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) were measured. TG/HDL was calculated.
Results: Significant trimester-dependent changes were observed in TG (p<0.001), HDL-C (p=0.017), and TG/HDL-C ratio (p<0.001). Post-hoc analysis indicated elevated TG and TG/HDL-C ratio in third trimester and peak HDL-C in second trimester.
Conclusion: TG, HDL-C, and TG/HDL-C ratio may serve as early biomarkers for identifying at-risk pregnancies. Monitoring these may aid in reducing adverse outcomes and long-term maternal morbidity.
Pregnancy; Triglyceride; HDL-C; TG/HDL-C Ratio
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Chidiadi M. Njoku, Samuel C. Meludu, Jude A. Onuegbu, Chidimma Okafor, Nosakhare O. Osakue nd Joy I. Onuora. Evaluation of anthropometric and lipid profile changes at different trimesters among pregnant women attending antenatal care in Nnewi, Anambra State, Nigeria. World Journal of Advanced Research and Reviews, 2025, 27(01), 818-822. Article DOI: https://doi.org/10.30574/wjarr.2025.27.1.2471.
Copyright © 2025 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0