Pediatric ophthalmology department; 20 August Hospital-Hassan II University, Casablanca.
World Journal of Advanced Research and Reviews, 2025, 27(01), 378-381
Article DOI: 10.30574/wjarr.2025.27.1.2536
Received on 26 May 2025; revised on 30 June 2025; accepted on 03 July 2025
We report the case of a 6-month-old infant with congenital megalocornea, microspherophakia, and bilateral lens subluxation, leading to secondary glaucoma. Genetic context included consanguinity, suggesting an LTBP2-related condition. The patient underwent bilateral lensectomy with anterior vitrectomy, combined with trabeculectomy and peripheral iridectomy in the right eye. Postoperative intraocular pressure normalized in both eyes. This rare entity should be distinguished from primary congenital glaucoma, as the surgical approach differs. Regular intraocular pressure monitoring is essential in children with megalocornea and lens anomalies to ensure early detection and treatment of secondary glaucoma.
Microspherophakia; Megalocornea; Ectopia Lentis; Secondary Glaucoma; LTBP2 Mutation; Case Report
Preview Article PDF
Ghizlane Daghouj, Sara Ennaki, Asmaa ElKettani, Zyad Laftimi, Loubna El Maaloum and Bouchra Allali. Congenital Megalocornea, Microspherophakia, and Lens Subluxation Leading to Secondary Glaucoma in an Infant: A Case of Suspected LTBP2 Mutation. World Journal of Advanced Research and Reviews, 2025, 27(01), 378-381. Article DOI: https://doi.org/10.30574/wjarr.2025.27.1.2536.
Copyright © 2025 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0