1 Department of Galenic Pharmacy and Pharmaceutical Legislation of the Faculty of Medicine and Biomedical Sciences of University of Yaounde I, Cameroon.
2 Department of Oral, Maxillofacial and Periodontal Surgery of the Faculty of Medicine and Biomedical Sciences of the University of Yaounde I, Cameroon.
3 Odonto Stomatology Department of the Central Hospital of Yaounde, Cameroon.
4 Department of Pharmaceutical Sciences of the Faculty of Medicine and Pharmaceutical Sciences of University of Ebolowa, Cameroon.
5 Institute for Medical Research and Studies on Medicinal Plants, Cameroon.
World Journal of Advanced Research and Reviews, 2025, 27(01), 1474-1479
Article DOI: 10.30574/wjarr.2025.27.1.2676
Received on 02 June 2025; revised on 13 July 2025; accepted on 16 July 2025
Tooth extraction can lead to complications such as bleeding and persistent pain, despite advances in dentistry. Conventional treatments are not always sufficient. Vernonia conferta Benth, a plant traditionally used for bacterial infections and skin conditions, possesses antimicrobial, hemostatic, and wound healing properties. This study aimed to formulate a healing gel based on an aqueous extract of its bark and evaluate its in vivo efficacy on wounds after simple tooth extraction.
The oral gel was formulated according to the method described by Nokam et al. A pilot study on 30 volunteer patients who underwent simple tooth extraction compared the gel's efficacy to standard antibiotic treatment. The 2% gel formulation had satisfactory physicochemical characteristics: dark brown color, pH 5.6 (compatible with saliva), soft consistency, mint odor, and slightly bitter taste. The results showed a more pronounced pain reduction with the gel. On day 2, 40% of patients in the gel group still felt pain, disappearing on day 3, compared to 66.70% for the antibiotic group. Regarding healing, the gel group showed a faster onset of healing. On day 3, 66.67% of patients in the gel group showed a reddish discoloration of the wound, a sign of granulation, compared to 26.67% in the other group. The beginning of closure of the extraction site was observed in 60% of patients in the gel group on day 3, while the antibiotic group reached this stage on day 7. At day 14, 66.70% of patients in the gel group were completely healed, compared to 40% in the other group.
In conclusion, the oral gel based on aqueous extract of Vernonia conferta Benth bark was relatively more effective for the healing of wounds following simple tooth extraction, offering a promising solution in dentistry.
Vernonia conferta; Oral Gel; Tooth Extraction; Healing; Pain; Stomatology
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Charlotte Vanessa Soppo Lobe Emanda, Marie Elvire Nokam Abena, Janyl Loïc Nsomoto, Henri Julien Nko’o Moïse, Félécité Chimène Benga Mekoulou, Martin Gogonet Emanda Ekoudi, Jacqueline Saurelle Foumane Maniepi Ngouopiho, Priscilla Bernadette Ndzie Maniben and Nnanga Nga. . Vernonia Conferta oral gel for wound healing after simple tooth extraction: Formulation and in vivo evaluation. World Journal of Advanced Research and Reviews, 2025, 27(01), 1474-1479. Article DOI: https://doi.org/10.30574/wjarr.2025.27.1.2676.
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