1 Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
2 Department of Periodontology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
World Journal of Advanced Research and Reviews, 2025, 25(01), 490-495
Article DOI: 10.30574/wjarr.2025.25.1.0052
Received on 25 November 2024; revised on 04 January 2025; accepted on 06 January 2025
Background: Periodontal disease, a common inflammatory condition caused by bacterial dysbiosis, leads to the destruction of connective tissue and tooth supporting tissue, and has a strong correlation with systemic disease. Sucralfate is a medication commonly used to treat epithelial wounds due to its strong anti-ulcer effects. It is also recognized for its antibacterial and anti-inflammatory properties. However, the regulatory effect of sucralfate on periodontal remains unclear. The article aims to review the potential of sucralfate in the treatment of periodontal disease.
Material and Methods: The literature review within the year 2019-2024 was carried out in ScienceDirect, PubMed and Google Scholar databases with the keywords: sucralfate, periodontal health, periodontal medication, oral health, antibacterial.
Results: Sucralfate demonstrates multiple beneficial properties for periodontal treatment, including forming protective barriers, reducing inflammation, and promoting wound healing. It shows promise in mitigating dental erosion, managing mucositis, and enhancing recovery in postoperative scenarios. However, its localized effects and minimal systemic absorption make it relatively safe, though side effects like constipation and rare cases of aluminum toxicity in renal-compromised individuals were noted.
Conclusions: Sucralfate has significant potential as an adjunctive treatment for periodontal disease, leveraging its cytoprotective, anti-inflammatory, and antibacterial properties. Despite its promise, further research is needed to address the heterogeneity of existing studies and to evaluate its clinical efficacy through standardized trials, enabling its integration into routine periodontal management.
Sucralfate; Periodontal Health; Periodontal Medication; Oral Health; Antibacterial
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Salwa Alya Putri, Rafie Wahyu Purnomo and Irma Josefina Savitri. The potential of sucralfate as adjunctive therapy in the treatment of periodontal disease: A review. World Journal of Advanced Research and Reviews, 2025, 25(01), 490-495. Article DOI: https://doi.org/10.30574/wjarr.2025.25.1.0052.
Copyright © 2025 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0