1 Department of Oral Biology, Faculty of Dental Medicine, Universitas Airlangga.
2 Department of Physiology, Faculty of Medicine, Universiti Malaya.
3 Faculty of Dental Medicine, Universitas Airlangga.
World Journal of Advanced Research and Reviews, 2025, 25(02), 1479-1484
Article DOI: 10.30574/wjarr.2025.25.2.0497
Received on 05 January 2025; revised on 13 February 2025; accepted on 16 February 2025
Background: Wound healing is a complex process involving hemostasis, inflammation, proliferation, and remodeling, which can be delayed by factors like hormonal changes. Estrogen plays a crucial role in regulating inflammation, collagen production, and angiogenesis during healing. In postmenopausal women, the decline in estrogen levels due to ovarian function cessation often leads to impaired healing, increased chronic inflammation, and a higher risk of infection. These challenges highlight the need to further explore the relationship between estrogen deficiency and wound healing, especially in the aging population where chronic wounds are more common.
Objectives: To review the relationship between estrogen deficiency, particularly in menopausal women, and its impact on the wound-healing process.
Conclusion: Estrogen deficiency delays wound healing by disrupting key processes like inflammation regulation and re-epithelialization, while increasing infection risk. Addressing this imbalance is crucial for improving recovery, especially in menopausal women.
Estrogen; Wound Healing; Chronic Inflammation, Public Health; Health Risk
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Aqsa Sjuhada Oki, Cheng Hwee Ming, Cindy Cahya Nabiilah and Jessica Amanda Hutapea. Estrogen deficiency and wound healing. World Journal of Advanced Research and Reviews, 2025, 25(02), 1479-1484. Article DOI: https://doi.org/10.30574/wjarr.2025.25.2.0497.
Copyright © 2025 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0