1 Department of Periodontology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
2 Dental Medicine Education Study Program, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
3 Department of Biochemistry, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
World Journal of Advanced Research and Reviews, 2025, 25(02), 2086-2092
Article DOI: 10.30574/wjarr.2025.25.2.0490
Received on 04 January 2025; revised on 13 February 2025; accepted on 16 February 2025
Background: Periodontitis is a chronic inflammatory disease initiated by bacterial dysbiosis in periodontal tissue. Porphyromonas gingivalis (P. gingivalis) is the keystone pathogen of periodontitis with the ability to promote systemic inflammation. They can invade other organs outside oral cavity and enter lymphatic and blood vessels. Its virulence factor can affect tissue integrity by disturbing extracellular matrix regulation, resulting in tissue destruction. One of the extracellular matrix components in facial skin is collagen, which is responsible for facial wrinkles.
Objectives: To examine collagen number density in rat facial skin due to Porphyromonas gingivalis induction in rat model periodontitis.
Methods: In vivo experimental study conducted with 2 control groups (C1, C2) and 2 treatment groups (T1, T2). The treatment groups received P. gingivalis induction for 3 weeks. The treatment group 1 (T1) euthanized 2 weeks after the bacterial induction, along with control group 1 (C1). The treatment group 2 (T2) was euthanized 4 weeks after the bacterial induction, along with control group 2 (C2). The facial skin was taken and prepared for Masson Trichrome staining. Statistical analysis was carried out for the collagen number density.
Results: There was significant difference in collagen number density between treatment groups and control groups (p < 0.05). In both treatment groups, the collagen number density is lower than both control groups.
Conclusions: There is a significant difference in collagen number density of rat facial skin between P. gingivalis induced and uninduced, and appears lower in rats induced by P. gingivalis.
Collagen; Facial Skin; Wrinkles; Periodontitis
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Nida Hana Salsabila, Aulia Ayu Adia, Antony Wijaya, Raihan Saputra, Shafira Kurnia Supandi, Wibi Riawan and Agung Krismariono. Decrease of collagen number density in rat facial skin due to Porphyromonas gingivalis induction in rat model periodontitis. World Journal of Advanced Research and Reviews, 2025, 25(02), 2086-2092. Article DOI: https://doi.org/10.30574/wjarr.2025.25.2.0490.
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