1 Veterinary Medicine Undergraduate Student, Department of Health and Agriculture Sciences, Santa Úrsula University, Fernando Ferrari, 75 – Botafogo Campus, Rio de Janeiro, Brazil.
2 Coordinator of Veterinary Medicine and Professor of Zoonoses & One health, Department of Health and Agriculture Sciences, Santa Úrsula University, Fernando Ferrari, 75 – Botafogo Campus, Rio de Janeiro, Brazil. Correspondence: rachel.simoes@usu.edu.br and coordenacao.medicinaveterinaria@usu.edu.br
3 Tropical Medicine, Vector Medical Malacology lato sensu postgraduate, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Avenida Brazil 4.365 – Manguinhos, Rio de Janeiro, Brazil.
World Journal of Advanced Research and Reviews, 2025, 25(03), 779-788
Article DOI: 10.30574/wjarr.2025.25.3.0716
Received on 27 January 2025; revised on 04 March 2025; accepted on 06 March 2025
Dengue is a vector-borne viral disease caused by the flavivirus dengue virus (DENV) that continue to circulate worldwide. A positive-stranded enveloped RNA virus (DENV) is principally transmitted by Aedes mosquitoes. It has four antigenically distinct serotypes, DENV-1 to DENV-4. This review highlights pathophysiology and clinical signs of Dengue Virus correlated with Heartworm Disease by Aedes aegypti mosquitoes, which transmit Dengue, Zika, Chikungunya and other arboviruses, had been modified genetically which carries a Wolbachia pipientis bacterium that stops the insect from transmitting viruses. There have been recent advances in the development of therapeutic drugs, and vaccines that are currently being pursued at several phases of preclinical and clinical development. The preventive measures of dengue transmission and challenging the epidemiological surveillance of the zoonotic diseases are the key role to control the spread of this vector through the improve the health promotion campaigns in water supply, personal protection, biological and mechanism vector approaches.
Aedes aegypti; Dengue virus; Heartworm; Vector-borne; Zoonotic diseases
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Nicoly Guimaraes Amaral Cabral, Giovanna dos Reis Brasiliense Cavalcante, Alexia Costa Leite, Guilherme Britto and Rachel Siqueira de Queiroz Simões. Risk of Aedes Aegypti as Biological Vector Transmissibility between Dengue Virus and Heartworm: Impact on the Pathogenesis of Zoonotic Diseases in Rural and Urban Environments. World Journal of Advanced Research and Reviews, 2025, 25(03), 779-788. Article DOI: https://doi.org/10.30574/wjarr.2025.25.3.0716.
Copyright © 2025 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0