1 Laboratory of Botany and Valorization of Plants Diversity, Department of Natural Sciences, Nangui Abrogoua University, Côte d’Ivoire.
2 Department of Governance and Sustainable Development, Bondoukou University, Côte d’Ivoire.
3 Laboratory of Biology and Health, Biology of Development and Reproduction Unit, Department of Biosciences, Félix Houphouët-Boigny University, Côte d’Ivoire.
4 Department of Sciences and Technology, Alassane Ouattara University, Côte d’Ivoire.
5 Swiss Center for Scientific Research Côte d’Ivoire (SCSR), Côte d’Ivoire.
World Journal of Advanced Research and Reviews, 2025, 25(03), 1440-1450
Article DOI: 10.30574/wjarr.2025.25.3.0871
Received on 10 February 2025; revised on 16 March 2025; accepted on 19 March 2025
Description of the subject. Andropause is a relatively important health and social problem that consequences are harmful to humans. In the therapy of this condition, the administration of testosterone is recommended.
Objective. This study aims to evaluate the androgenic power of some medicinal plants from Côte d’Ivoire.
Methods. Biological investigations on sperm parameters and testosterone levels were carried out by oral administration of different aqueous extracts of Cissus aralioides, Palisota hirsuta, Zanthoxylum gilletii and Euphorbia hypericifolia to mature male rat. This administration was done over 35 successive days, at a dose of 100 mg/Kg body weight.
Results. Administration of the different extracts induced an increase in serum testosterone levels in the treated animals. The aqueous extracts of the whole plant of E. hypericifolia and the stem bark of Z. gilletii respectively induced the greatest increase in serum testosterone (15.61±0.34 ng/mL and 11.87±0.35 ng/mL) versus 0.83±0.18 ng/mL for the control group. The sperm densities of the E. hypericifolia (~78.106 spz/mL ± 2.93) and Z. gilletii (~62.94 × 106 spz/mL ± 2.44) groups were higher than those of the control group (~63.95 × 106 spz/mL ± 2.93) with (p < 0.001). The percentage of motile sperm was higher in the E. hypericifolia group (~79%±0.00%) than in the control group (~17±0.01%), with p < 0.001.
Conclusions. These different results show that these plant species improve spermatogenesis.
Medicinal plants; Sperm parameters; Testosterone; Côte d’Ivoire
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Brahima Kandé, Any Georges Armel Moyabi, Maïmouna Coura Koné, Roger Koffi Kouakou, Hervé Aka Aka, Bruce Hermann Kouadio Koffi and Mamidou Witabouna Koné. Evaluation of the androgenic activity of some medicinal plants in the case of andropause (Côte d’Ivoire). World Journal of Advanced Research and Reviews, 2025, 25(03), 1440-1450. Article DOI: https://doi.org/10.30574/wjarr.2025.25.3.0871.
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